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JOURNAL ARTICLE
RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
REVIEW
Heterotrimeric G-protein regulatory circuits in plants: Conserved and novel mechanisms.
Plant Signaling & Behavior 2017 June 4
ARTICLE ADDENDUM Efficient activation and deactivation of Gα protein is critical for the regulation of heterotrimeric G-protein mediated signaling pathways. While the core G-protein components and their activation/deactivation chemistries are broadly conserved throughout the eukaryotic evolution, their regulatory mechanisms seem to have been rewired in plants to meet specific needs. Plants such as Arabidopsis, which have a limited number of G-protein components and their regulators, offer a unique opportunity to dissect the mechanistic details of distinct signaling pathways. We have recently established an interaction between the regulator of G-protein signaling 1 (RGS1) and phospholipase Dα1 (PLDα1); 2 of the GTPase activity accelerating proteins (GAPs) of the Arabidopsis Gα protein, GPA1. We now show that phosphatidic acid (PA), a key product of PLDα1 activity, can bind with and modulate the GAP activity of RGS1, uncovering a molecular link between lipid and G-protein signaling and its role in providing the specificity of response regulation.
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