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Genome Organization: Cohesin on the Move.

Judita Richterova, Barbora Huraiova, Juraj Gregan
Molecular Cell 2017 May 19
Folding of mammalian genomes into spatial domains is thought to depend on cohesin and CTCF proteins. Busslinger et al. (2017) reveal that transcription moves cohesin along DNA to CTCF-binding sites, providing insights into how cohesin and CTCF mediate chromosomal interactions by formation of chromatin loops.

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