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A guide for targeted SUMO removal.

Nalini Dhingra, Xiaolan Zhao
Genes & Development 2017 April 16
SUMO homeostasis is important for many cellular processes. In the current issue of Genes & Development , Liang and colleagues (pp. 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for removing SUMO from specific substrates and how curtailing sumoylation levels can regulate transcription in this nuclear compartment.

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