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[The nonalcoholic steatohepatitis influence on the course and progression of ischemic heart disease].

INTRODUCTION: Nonalcoholic steatohepatitis (NASH) can be considered a risk factor of progression of diseases associated with atherosclerosis, especially ischemic heart disease (IHD) with a high probability of early myocardial infarction (MI).

AIM: To study the peculiarities and nature of ischemic heart disease clinical picture in patients with concomitant NASH.

MATERIALS AND METHODS: The study involved 58 patients with ischemic heart disease. The nature of ischemic heart disease according to outpatients was evaluated, an assessment of ECG, echocardioscopy changes and Holter-monitoring was performed.

RESULTS: The ischemic heart disease and concomitant NASH was observed only in young and middle age patients, among whom 16 (61.5%) revealed the presence of visceral obesity type. The presence of this synthropy is accompanied by an aggressive course of coronary heart disease with early MI development. According to Seattle Angina Questionnaire scale is case of IHD with NASH combination more limitation of physical activity, less pleasure treatment, worse perception of the disease and a significant reduction in the life quality of patients were noted. The nature of myocardium bioelectric activity disorders did not differ in the comparison group and matched the angina functional class and myocardial infarction consequences.

CONCLUSIONS: The presence of visceral obesity, NASH causes early and aggressive course of ischemic heart disease, which is accompanied by a high risk of MI and reduces the patients' quality of life.

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