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Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases.
Journal of Rheumatology 2017 September
OBJECTIVE: Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.
METHODS: The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.
RESULTS: The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.
CONCLUSION: Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
METHODS: The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.
RESULTS: The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.
CONCLUSION: Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
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