Add like
Add dislike
Add to saved papers

Iodine-loaded metal organic framework as growth-triggered antimicrobial agent.

Zeolitic imidazolate framework-8 (ZIF-8) is one of easily available metal organic frameworks because of its facile preparation via mixing aqueous solutions of zinc nitrate and 2-methylimidazole. It turned into a very effective pH-responsive bactericide after loading with iodine. Approximately, 0.9g of iodine could be readily loaded into one gram of ZIF-8 from iodine dissolved n-heptane solution. Both Gram-negative Escherichia coli and Gram-positive Staphylococcus epidermidis and Staphylococcus aureus could be very effectively killed by iodine loaded ZIF-8 (ZIF-8@I) at pH6.0 within 3min. In contrast, at pH above 7.0, no appreciable antimicrobial activity could be detected. The bacteria killing effect is resulted from the iodine released from ZIF-8@I disintegrated at acidic pH. ZIF-8@I coated surface also showed its acidic pH-triggered antimicrobial activity against deposited bacterial cells. The antimicrobial activity of ZIF-8@I against actively grown bacterial lawns on a pH neutral agar plate was also observed. The result demonstrates that iodine was released from the disintegrated ZIF-8@I to kill bacteria in response to the bacterial growth-induced pH lowering.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app