The Study of Calcium, Phosphonium, Magnesium, and Ferrum Concentration in Serum of Patients With Primary Trigeminal Neuralgia.

OBJECTIVE: To measure the concentration of 4 essential elements (Ca, P, Mg, Fe) in serum of patients with primary trigeminal neuralgia. And evaluate the role of the 4 elements in serum on the pathogenesis of trigeminal neuralgia (TN), and the relevance of etiology.

METHODS: From June 2013 to June 2014, a number of 80 patients with primary trigeminal neuralgia were collected. We present a retrospective review of the concentration of 4 essential elements with those of control group of 80 patients without TN. The concentrations of 4 elements were measured with Olympus AU 400 automatic biochemistry analyzer.

RESULTS: In primary TN patients, the concentration of Ca, P, Mg in serum is lower than the control group obviously (P <0.05), but the concentration of Fe in serum is higher than the control group obviously (P <0.05). Along with level of the VOS improved, the concentration of Ca, P, and Mg in serum becomes lower and lower. However, along with level of the VOS improved, the concentration of Fe in serum becomes higher and higher.

CONCLUSION: Patients with primary TN, the change of 4 elements concentration in serum is connected with biochemical material change. The change of the microelement may play an important role in the development of Trigeminal neuralgia, possibly demyelinating lesions.