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Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors.
Bioorganic & Medicinal Chemistry Letters 2017 June 16
A series of substituted indoles were examined as selective inhibitors of tropomyosin-related kinase receptor A (TrkA), a therapeutic target for the treatment of pain. An SAR optimization campaign based on ALIS screening lead compound 1 is reported.
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