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Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative.

E A Novoselova, O B Riabova, I A Leneva, V G Nesterenko, R N Bolgarin, V A Makarov
Acta Naturae 2017 January
A novel compound, 3,3'-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell's surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses.

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