We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Multiple Approaches to the In Situ Generation of Anhydrous Tetraalkylammonium Fluoride Salts for S N Ar Fluorination Reactions.
Journal of Organic Chemistry 2017 May 20
This article focuses on the development of practical approaches to the in situ generation of anhydrous fluoride salts for applications in nucleophilic aromatic substitution (SN Ar) reactions. We report herein that a variety of combinations of inexpensive nucleophiles (e.g., tetraalkylammonium cyanide and phenoxide salts) and fluorine-containing electrophiles (e.g., acid fluoride, fluoroformate, benzenesulfonyl fluoride, and aryl fluorosulfonate derivatives) are effective for this transformation. Ultimately, we demonstrate that the combination of tetramethylammonium 2,6-dimethylphenoxide and sulfuryl fluoride (SO2 F2 ) serves as a particularly practical route to anhydrous tetramethylammonium fluoride. This procedure is applied to the SN Ar fluorination of a range of electron-deficient aryl and heteroaryl chlorides as well as nitroarenes.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app