[THE INFLUENCE OF LIFESTYLE ON BIOMARKERS OF FIBROSIS IN PATIENTS WITH STABLE CORONARY HEART DISEASE ON THE BACKGROUND OF NON-ALCOHOLIC FATTY LIVER DISEASE].

Purpose - to assess the impact of lifestyle on non-alcoholic fatty liver disease (NAFLD) activity by influencing the fibrotic processes and hepatic steatosis in patients with stable coronary heart disease (CHD). 105 patients with stable CHD, combined with NAFLD were observed: Group I - control group; Group II - basic group. In each group, patients with non-alcoholic steatosis (subgroup A) and non-alcoholic steatohepatitis (subgroup B) were isolated. General clinical examination, electrocardiography, coronary angiography, echocardiography, liver functional state, serum lipid profile, fasting glucose, markers of fibrosis were conducted to all patients. After treatment in patients of Group II positive changes in all parameters vs. basal levels and the control group were found: significantly decreased body mass index, alpha-2-macroglobulin and type IV collagen levels; increased apolipoprotein A1 and haptoglobulin levels; decreased severity of dyslipidemia; improved parameters of the liver functional state. Modification of lifestyle of patients with stable CHD influences positively on the NAFLD course, reducing disease activity by inhibiting fibrotic processes and hepatic steatosis that, in general, inhibits the progression of this comorbid disorder.