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Reconciling Epigenetic Memory and Transcriptional Responsiveness.

Amanda G Fisher, Michael P H Stumpf, Matthias Merkenschlager
Cell Systems 2017 April 27
The molecular basis of cellular memory is important but poorly understood. Using estimates of histone dynamics, Martin Howard and colleagues construct a mathematical model that helps to explain both the stability and flexibility of Polycomb-mediated gene regulation in cellular memory.

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