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SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells.

Tong Ming Liu, Ng Shyh-Chang
Nature Cell Biology 2017 April 28
The metabolic transition from mitochondrial oxidative phosphorylation (OXPHOS) to glycolysis is critical for somatic reprogramming of induced pluripotent stem cells (iPSCs). SIRT2 has now been established as a previously unknown regulator of this metabolic transition during somatic reprogramming by controlling the acetylation status of glycolytic enzymes.

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