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Terminating the replication helicase.

Vincent Gaggioli, Philip Zegerman
Nature Cell Biology 2017 April 28
A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

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