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JOURNAL ARTICLE
REVIEW
Clarifying complex inheritance: apolipoprotein C3 and atherosclerosis.
Current Opinion in Lipidology 2017 August
PURPOSE OF REVIEW: To describe some steps in the progress in the molecular biology of a peptide, apolipoprotein C3; its gene mutations that render individuals susceptible or resistant to developing hyperlipidaemia and atherosclerosis.
RECENT FINDINGS: Data that lead to the development of a new therapeutic agent volanesorsen.
SUMMARY: The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals).
RECENT FINDINGS: Data that lead to the development of a new therapeutic agent volanesorsen.
SUMMARY: The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals).
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