Relationship between serum uric acid and ischemic stroke in a large type 2 diabetes population in China: A cross-sectional study.

OBJECTIVE: To investigate the relationship of serum UA and ischemic stroke in type 2 diabetes patients in China.

METHOD: We examined the above relationship using the data of the project "Comprehensive Research on the Prevention and Control of the Diabetes" (CRPCD) study. A total of 19,442 participants were enrolled in the cross-sectional study. The enrolled participants were divided into quintiles of the serum UA levels with cut off values for two age groups (<60 versus ≥60years). Binary logistic regression analyses were used to evaluate whether the levels of serum UA were independently associated with ischemic stroke in type 2 diabetes.

RESULTS: The serum UA levels were significantly higher in the participants with age≥60years than those with age<60years (P=0.000). In the age group of <60years, the odds ratio for ischemic stroke with type 2 diabetes in quintile 5 over quintile 1 was 2.420 (95% CI, 1.566-3.470) in the unadjusted model and 1.765 (95% CI, 1.097-2.840) after controlling potential confounders. However, the reverse results were observed in the age group of ≥60years. The odds ratio in quintile 4 over quintile 1 in model 3 and model 4 were 0.767 (95% CI, 0.630-0.934) and 0.782 (95% CI, 0.640-0.957).

CONCLUSION: Our results indicated that serum UA levels were independently positively associated with ischemic stroke in patients aged <60years, but the association was U-shaped in patients aged ≥60years.