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Hormonal regulation of NK cell cytotoxic activity.
Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections 2017 January
The effects of chorionic gonadotropin, estriol (E3 ), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
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