We have located links that may give you full text access.
Integration of Functional MRI and White Matter Tractography in CyberKnife Radiosurgery.
Technology in Cancer Research & Treatment 2017 January 2
PURPOSE: To investigate the efficacy of the integration of functional magnetic resonance imaging and diffusion-tensor imaging tractography data into CyberKnife radiosurgery for intracranial tumor management.
MATERIALS AND METHODS: Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before radiosurgery. The acquired data sets were coregistered using the MIM image fusion software module and then were imported into the CyberKnife Robotic Radiosurgery System (Multiplan 4.0.2) for delineating the target, organs at risk, and possible nearby functionally relevant cortical and subcortical areas. Radiation dose distributions with and without the functionally relevant cortical and subcortical areas into the optimization process were developed and compared.
RESULTS: There were significant differences between the treatment plans with and without the functionally relevant cortical and subcortical areas into the optimization process. An average 22.71% reduction in the maximum dose to functional areas was observed. No neurological complication due to radiation damage was observed in the follow-up period.
CONCLUSION: The functional neuroimaging could be easily and reliably integrated into the CyberKnife treatment planning. Consideration of functional structures and fiber tracts during treatment planning could clinically reduce the radiation doses to these critical structures, thereby preserving its unique function of brain.
MATERIALS AND METHODS: Functional neuroimaging, anatomical magnetic resonance imaging, and computed tomography images of patients with brain lesions in critical areas were acquired before radiosurgery. The acquired data sets were coregistered using the MIM image fusion software module and then were imported into the CyberKnife Robotic Radiosurgery System (Multiplan 4.0.2) for delineating the target, organs at risk, and possible nearby functionally relevant cortical and subcortical areas. Radiation dose distributions with and without the functionally relevant cortical and subcortical areas into the optimization process were developed and compared.
RESULTS: There were significant differences between the treatment plans with and without the functionally relevant cortical and subcortical areas into the optimization process. An average 22.71% reduction in the maximum dose to functional areas was observed. No neurological complication due to radiation damage was observed in the follow-up period.
CONCLUSION: The functional neuroimaging could be easily and reliably integrated into the CyberKnife treatment planning. Consideration of functional structures and fiber tracts during treatment planning could clinically reduce the radiation doses to these critical structures, thereby preserving its unique function of brain.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app