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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Uranyl Photocleavage of Phosphopeptides Yields Truncated C-Terminally Amidated Peptide Products.
Chembiochem : a European Journal of Chemical Biology 2017 June 20
The uranyl ion (UO2 2+ ) binds phosphopeptides with high affinity, and when irradiated with UV-light, it can cleave the peptide backbone. In this study, high-accuracy tandem mass spectrometry and enzymatic assays were used to characterise the photocleavage products resulting from the uranyl photocleavage reaction of a tetraphosphorylated β-casein model peptide. We show that the primary photocleavage products of the uranyl-catalysed reaction are C-terminally amidated. This could be of great interest to the pharmaceutical industry, as efficient peptide amidation reactions are one of the top challenges in green pharmaceutical chemistry.
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