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Dasatinib Use and Risk of Cytomegalovirus Reactivation After Allogeneic Hematopoietic-Cell Transplantation.

Daniel P Prestes, Esther Arbona, Alexandra Nevett-Fernandez, Ann E Woolley, Vincent T Ho, Sophia Koo, Lindsey R Baden, John Koreth, Sarah P Hammond, Nicolas C Issa, Francisco M Marty
Clinical Infectious Diseases 2017 August 2
Viral infections have been reported with dasatinib use, but its cytomegalovirus risk after hematopoietic-cell transplantation (HCT) is not known. We found that post-HCT dasatinib use increased the risk of cytomegalovirus reactivation (adjusted hazard ratio, 7.65; 95% confidence interval, 1.84-31.7), controlling for acute graft-versus-host disease, in 109 patients with Philadelphia-chromosome-positive malignancies.

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