We have located links that may give you full text access.
A posterior-to-anterior shift of brain functional dynamics in aging.
Brain Structure & Function 2017 November
Convergent evidence from task-based functional magnetic resonance imaging (fMRI) studies suggests a posterior-to-anterior shift as an adaptive compensatory scaffolding mechanism for aging. This study aimed to investigate whether brain functional dynamics at rest follow the same scaffolding mechanism for aging using a large Chinese sample aged from 22 to 79 years (n = 277). We defined a probability of brain regions being hubs over a period of time to characterize functional hub dynamic, and defined variability of the functional connectivity to characterize dynamic functional connectivity using resting-state fMRI. Our results revealed that both functional hub dynamics and dynamic functional connectivity posited an age-related posterior-to-anterior shift. Specifically, the posterior brain region showed attenuated dynamics, while the anterior brain regions showed augmented dynamics in aging. Interestingly, our analysis further indicated that the age-related episodic memory decline was associated with the age-related decrease in the brain functional dynamics of the posterior regions. Hence, these findings provided a new dimension to view the scaffolding mechanism for aging based on the brain functional dynamics.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app