Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases.

Song-Yang Zhang, Ming-Jiang Xu, Xian Wang

British Journal of Pharmacology 2018 April

Adrenomedullin (ADM) 2/intermedin (IMD) is a short peptide that belongs to the CGRP superfamily. Although it shares receptors with CGRP, ADM and amylin, ADM2 has significant and unique functions in the cardiovascular system. In the past decade, the cardiovascular effect of ADM2 has been carefully analysed. In this review, progress in understanding the effects of ADM2 on the cardiovascular system and its protective role in cardiometabolic diseases are summarized.

LINKED ARTICLES: This article is part of a themed section on Spotlight on Small Molecules in Cardiovascular Diseases. To view the other articles in this section visit https://onlinelibrary.wiley.com/doi/10.1111/bph.v175.8/issuetoc.

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