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Journal Article
Review
The use of vaccines to control pathogen spread in pig populations.
Vaccine efficacy has often been studied from the viewpoint of individual direct clinical protection. For several vaccines, a decrease in pathogen shedding in vaccinated animals has also been documented, which suggests that transmission between individuals has the potential to be reduced. In addition, vaccination induces an immune response in the host potentially decreasing susceptibility to infection in comparison with immunologically naïve animals. As a collective result of individual vaccinations, vaccine programmes generally have a wider impact on pathogen diffusion at the population scale. Beyond the individual protection conferred by mass vaccination campaigns, the indirect protection of non-immune individuals in contact with vaccinated ones also contributes to controlling pathogen spread at the population scale; a phenomenon known as herd immunity. Pathogen spread within pig populations is strongly related to the required vaccine coverage at the population level and to pathogen characteristics in terms of diffusion ([Formula: see text]). Before setting up vaccination programmes, it is therefore necessary to have quantitative knowledge on vaccine efficacy as regards transmission reduction. These data can be obtained by carrying out experimental studies or observational protocols in real conditions. These quantitative data have mainly been estimated for major infectious diseases which have now been eradicated. A great gap in knowledge has however been identified for enzootic diseases which are daily impacting the swine sector as well as for the source of variation responsible for a decrease in vaccine efficacy as compared to assessments obtained in experimental conditions.
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