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Targeting the AXL signaling pathway in ovarian cancer.

Ruby Yun-Ju Huang, Jane Antony, Tuan Zea Tan, David Shao-Peng Tan
Molecular & Cellular Oncology 2017
In a recent publication in Science Signaling , we showed that a Mes molecular subtype of epithelial ovarian cancer (EOC) harboring epithelial-mesenchymal transition (EMT) features has a unique signaling network downstream of the GAS6/AXL pathway. Our finding leads to a potential strategy for treating the Mes subtype of EOC by targeting AXL.

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