[Generation of GABAergic interneuron-specific PGC-1α knockout mice].

OBJECTIVE: To generate mice which are specific for peroxisomproliferator-activated receptor-γ coactivator-1(PGC-1α) knockout in the GABAergic interneuron.

METHODS: Conditional mice specific for PGC-1α(f/+) were introduced from the Jackson Laboratory, USA and initially inbred to obtain homozygote PGC-1α (f/f) mice. The PGC-1α(f/f) conditional mice were further crossed with Dlx5/6-Cre-IRES-EGFP transgenic mice to achieve specific knockout of PGC-1α in the GABAergic interneuron.

RESULTS: The offspring with specific knockout PGC-1α gene were successful for the generation of GABAergic interneuron, with the resulting genotype being PGC-1α (f/f;Dlx5/6-Cre-IRES-EGFP).

CONCLUSION: The PGC-1α (f/f;Dlx5/6-Cre-IRES-EGFP) mice were obtained through a proper crossing strategy, which has provided a suitable platform for studying the function of PGC-1α in neuropsychiatric diseases.