Next Generation Sequencing and Multi-Gene Panel Testing: Implications for the Oncology Nurse.

OBJECTIVES: To review past, current, and future events in genetics and discuss how genetic testing information personalizes cancer screening, detection, and treatment. A case study is presented to illustrate key points.

DATA SOURCES: National guidelines, evidence-based summaries, peer-reviewed studies, editorials, and web sites.

CONCLUSION: Multi-gene testing using next-generation sequencing has changed the landscape for hereditary cancer syndromes.

IMPLICATIONS FOR NURSING PRACTICE: Nurses have key roles in personalizing health care including recognizing the complexities of genetic testing, assessing family history, understanding gene/environment factors, referring for genetics consultations, and promoting registry studies. In order to be effective, nurses must stay current with the rapidly-changing technology and guidelines for genetic evaluations and testing.