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Comparison of imipenem and meropenem antibiotics for the MALDI-TOF MS detection of carbapenemase activity.

Veronika Rotova, Costas C Papagiannitsis, Anna Skalova, Katerina Chudejova, Jaroslav Hrabak
Journal of Microbiological Methods 2017 June
A comparison of carbapenem molecules for the detection of carbapenemase-producing bacteria by MALDI-TOF MS showed that imipenem exhibited higher sensitivity (97%) and specificity (100%) scores for Pseudomonas aeruginosa than meropenem. However, meropenem was more efficient (98% sensitivity and 100% specificity) against Enterobacteriaceae.

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