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New Avermectin Analogues from a Mutant Streptomyces avermectinius Strain.
Chemistry & Biodiversity 2017 July
Two new avemectin analogues 1 and 2 belonging to 'b' series of components were isolated from a ∆aveCDE mutant Streptomyces avermectinius strain. Their structures were elucidated by detailed analysis of NMR and MS spectroscopic data. Compounds 1 and 2 displayed moderate cytotoxicities against B16, MG-63, and Saos-2 cell lines in an in vitro assay.
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