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Cancer and the omics revolution.
BACKGROUND: Internal medicine is in flux because of the 'omics revolution', with cancer medicine being a good example. Molecular technologies that detect alterations in gene-based structure or function are having an impact on diagnosis, prognosis and treatment of cancer.
OBJECTIVE: In this article, recent advances in gene-based characterisation of cancer are presented, and illustrated where possible by clinical applications.
DISCUSSION: The research-based vision of precision medicine is now on its way to becoming a clinical reality. A key limiting factor is the small number of therapeutic options available for customisation, which contrasts with the rising abundance of omics-derived data. However, further translational progress is anticipated over the next decade.
OBJECTIVE: In this article, recent advances in gene-based characterisation of cancer are presented, and illustrated where possible by clinical applications.
DISCUSSION: The research-based vision of precision medicine is now on its way to becoming a clinical reality. A key limiting factor is the small number of therapeutic options available for customisation, which contrasts with the rising abundance of omics-derived data. However, further translational progress is anticipated over the next decade.
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