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Detection of DT-diaphorase Enzyme with a ParaCEST MRI Contrast Agent.

Iman Daryaei, Kyle M Jones, Mark D Pagel
Chemistry : a European Journal 2017 May 12
A responsive magnetic resonance (MRI) contrast agent has been developed that can detect the enzyme activity of DT-diaphorase. The agent produced different chemical exchange saturation transfer (CEST) MRI signals before and after incubation with the enzyme, NADH, and GSH at different pH values whereas it showed good stability in a reducing environment without enzyme.

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