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First Report of Hb Limassol [β8(A5)Lys→Asn; HBB: c.27G>C] from Odisha, India.

Satyabrata Meher, Snehadhini Dehury, Arpita Jana, Subhra Bhattacharya, Amrita Patel, Kishalaya Das, Siris Patel, Biswanath Sarkar, Pradeep Kumar Mohanty
Hemoglobin 2016 November
In this short report, we describe the clinical presentation of a rare hemoglobin (Hb) variant, Hb Limassol [β8(A5)Lys→Asn; HBB: c.27G>C] with a faster electrophoretic mobility than Hb A and that elutes in the P3 window on cation exchange high performance liquid chromatography (HPLC). This sequence variation at codon 8 (AAG>AAC) of the HBB gene was found in the four heterozygous cases, all of whom were clinically asymptomatic.

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