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Journal Article
Research Support, Non-U.S. Gov't
Biophysical characterization of the Varroa destructor Na V 1 sodium channel and its affinity for τ-fluvalinate insecticide.
The decline of the western honeybee ( Apis mellifera ) has been reported to be due to parasitism by Varroa destructor mites and to colony collapse disorder in which these mites may be involved. In-hive chemicals such as τ-fluvalinate are being used to control V destructor populations. This approach may lead to the chronic exposure of bees to this liposoluble chemical, which tends to accumulate in hives. We cloned a variant of the V. destructor voltage-dependent sodium (VdNaV 1) channel and studied its biophysical characteristics and sensitivity to τ-fluvalinate using the Xenopus oocyte expression system and the 2-microelectrode voltage-clamp technique. We compared the affinity of VdNaV 1 for τ-fluvalinate with the honeybee voltage-dependent sodium ortholog. Our results showed that the honeybee sodium channel is more sensitive to τ-fluvalinate than the V. destructor channel, suggesting that care must be taken when treating hives with this chemical.-Gosselin-Badaroudine, P., Chahine, M. Biophysical characterization of the Varroa destructor NaV 1 sodium channel and its affinity for τ-fluvalinate insecticide.
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