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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
A fly view on the roles and mechanisms of the m 6 A mRNA modification and its players.
RNA Biology 2017 September 3
RNA modifications are an emerging layer of posttranscriptional gene regulation in eukaryotes. N6 -methyladenosine (m6 A) is among the most abundant modifications in mRNAs (mRNAs) that was shown to influence many physiological processes from yeast to mammals. Like DNA methylation, m6 A in mRNA is dynamically regulated. A conserved methyltransferase complex catalyzes the deposition of the methyl group on adenosine, which can be removed by specific classes of demethylases. Furthermore, YTH-domain containing proteins can recognize this modification to mediate m6 A-dependent activities. Here we review the functions and mechanisms of the main m6 A players with a particular focus on Drosophila melanogaster.
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