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Pico-HPLC system integrating an equal inner diameter femtopipette into a 900 nm I.D. porous layer open tubular column.

Ruonan Li, Yunlong Shao, Yanmin Yu, Xiayan Wang, Guangsheng Guo
Chemical Communications : Chem Comm 2017 April 7
A picoflow high performance liquid chromatography (pico-HPLC) system was developed, which could directly pipette femtoliter samples using a separation column tip driven by an electroosmotic pump. Amino acid enantiomers were separated in the 900 nm I.D. porous layer open tubular column at a flow rate of 13.50 pL min-1 .

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