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TIR Axons Apart: Unpredicted NADase Controls Axonal Degeneration.
Neuron 2017 March 23
SARM1 is a key regulator of axonal degeneration. However, SARM1 mechanism of action is not clear. In this issue of Neuron, Essuman et al. (2017) reveal an intrinsic NADase activity in the SARM1-TIR domain that is required for axonal degeneration.
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