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Me 3 SiCF 2 Br-Self-Assisted Domino Reaction: Catalytic Synthesis of α,α-Difluorocyclopentanones from Methylvinylketones.

Organic Letters 2017 April 8
A complete self-assistance strategy based on Me3 SiCF2 Br was used in the domino conversion of methylvinylketones into α,α-difluorinated cyclopentanones. Initiated by 5 mol % of nBu4 NBr, the multistep reaction occurred in one pot under mild conditions via the in situ formation of silyl dienol ethers, difluorocyclopropanation, thermal vinylcyclopropane-cyclopentene rearrangement, and desilylation. The process takes advantage of the multitasking capability of Me3 SiCF2 Br as the difluorocarbene source, a silicon-based transfer agent, and a bromine anion releaser.

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