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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Macrophages: micromanagers of antagonistic signaling nanoclusters.
Journal of Cell Biology 2017 April 4
How cells integrate antagonistic receptor signaling events is enigmatic. Using superresolution optical microscopy, Lopes et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608094) demonstrate the nanometer-scale molecular reorganization of antagonistic signaling receptors in macrophages, after engagement by the receptors of activating and inhibitory ligands. They propose that large-scale rearrangements of this type underpin decision-making by these cells.
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