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Journal Article
Research Support, Non-U.S. Gov't
One-Pot Multicomponent Synthesis of β-Amino Amides.
Angewandte Chemie 2017 April 11
Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one-pot multicomponent synthesis of β-amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.
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