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Unsymmetrical Iron P-NH-P' Catalysts for the Asymmetric Pressure Hydrogenation of Aryl Ketones.

The reductive amination of α-dialkylphosphine acetaldehydes with enantiopure β-aminophosphines is a new, versatile route to unsymmetrical tridentate (pincer) ligands P-NH-P'. Four new ligands PR2 CH2 CH2 NHCHR'CHR''PPh2 (R=iPr, Cy, R'=Ph, CH(CH3 )2 , R''=Ph, H) prepared in this way are used to make the iron(II) complexes mer-FeCl2 (CO)(P-NH-P') and mer-FeCl(H)(CO)(P-NH-P'). The hydride complex with the rigid ligand with R'=R''=Ph is an efficient and highly enantioselective homogeneous asymmetric pressure hydrogenation (APH) catalyst. Prochiral aryl ketones are reduced under mild conditions (THF, 0.1 mol % catalyst, 1 mol % KOtBu, 5-10 bar, 50 °C) to the (S)-alcohols, usually in enantiomeric excess (ee) greater than 90 %. DFT calculations provided transition-state structures for the enantiodetermining hydride-transfer step.

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