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Intestinal transcriptome modulation by functional diets in rainbow trout: A high-throughput sequencing appraisal to highlight GALT immunomodulation.
Fish & Shellfish Immunology 2017 May
Functional ingredients such as pre- and probiotics are used in aquaculture to improve fish condition, modulating microbiota and promoting a healthy intestinal functioning. They also exert an active effect on the gut associated lymphoid tissue (GALT), stimulating the immune system. However, the molecular underpinnings of pre- and probiotics effect on intestinal mucosa are still unknown. This study investigated the intestinal mucosa transcriptome modulation when fish were fed functional diets and kept at different stocking densities. Juvenile rainbow trout were kept at low (LD-3Kgm-3) and high density (HD-40 kgm-3) and fed for 30 days functional diets with the prebiotic mannanoligosaccharide (PRE-0.6%), the probiotic Saccharomyces cerevisiae (PRO-0.5%), the mixture of both (MIX) and a control diet (CTRL). Intestinal transcriptome was evaluated by high-throughput sequencing and blood plasma for biochemical parameters. Fish fed functional diets presented better condition regardless density, and that functional diets modulate intestinal transcriptome in different manner depending on the stocking density. At LD, fish from PRO presented stronger modulation with the majority of transcripts being down-regulated, including the immune related ones, whereas at HD both PRO and MIX groups were more modulated, when comparing to the respective CTRL groups. Density had an overwhelming suppressive effect on the immune-related genes, but this effect was counteracted by feeding functional diets, especially in fish fed with probiotics. This study shows for the first time the intestinal transcriptomic modulation when fish are fed functional diets at different stocking densities, and it shows the mitigating effect of these diets against deleterious conditions such as high density.
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