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[Myocardial Infarction and Natural Defense Mechanisms: The Role of Norepinephrine Reuptake].
Kardiologiia 2016 May
PURPOSE: to study effect of norepinephrine reuptake blockade in reperfusion period on size of infarct caused by local ischemia with and without ischemic pre- and postconditioning.
MATERIAL AND METHODS: Wistar rats (n=46) were randomly divided into 6 groups. Group (gr) I (n=7) - 30 min occlusion of left coronary artery followed by 120 reperfusion; gr II (n=2) as in gr I +desipramine (0.8 mg/kg intravenously [i.v.]) at the start of reperfusion; gr III (n=6) - ischemic preconditioning before coronary artery occlusion; gr IV (n=7).
MATERIAL AND METHODS: Wistar rats (n=46) were randomly divided into 6 groups. Group (gr) I (n=7) - 30 min occlusion of left coronary artery followed by 120 reperfusion; gr II (n=2) as in gr I +desipramine (0.8 mg/kg intravenously [i.v.]) at the start of reperfusion; gr III (n=6) - ischemic preconditioning before coronary artery occlusion; gr IV (n=7).
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