N-Pyrrylarylsulfones with High Therapeutic Potential.

This review illustrates the various studies made to investigate the activity of N -pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure-activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N -pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N -pyrrylarylsulfone based agents.