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Journal Article
Research Support, Non-U.S. Gov't
Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.
Bioorganic & Medicinal Chemistry Letters 2017 April 16
We report the synthesis of two new artificial nucleobase scaffolds, 1 and 2, featuring adequate hydrogen bonding donors and acceptors for the molecular recognition of U:A and C:G base pairs, respectively. The tethering of these structures to various amino acids and the assessment of these artificial nucleobase-amino acid conjugates as RNA ligands against a model of HCV IRES IIId domain are also reported. Compound 1e displayed the highest affinity (Kd twice lower than neomycin - control). Moreover, it appears that this interaction is enthalpically and entropically favored.
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