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[Identification of HLA class Ⅱ susceptible alleles and genotypes in latent autoimmune diabetes in adults].

Objective: To identify human leukocyte antigen (HLA)-DRB1, DQA1 and DQB1 susceptible alleles and genotypes in latent autoimmune diabetes in adults (LADA) patients of Chinese Han nationality. Methods: All subjects including 652 LADA patients and 1 181 healthy controls from 1999 to 2015 in Han nationality region of Hunan province were genotyped with high resolution at HLA-DRB1, DQA1 and DQB1 locus by PCR-sequence based typing (PCR-SBT). Frequencies of genotypes between patients and controls were compared by chi square test. Results: The DQA1 susceptible allele was DQA1*03 ( OR =1.23, P (c)=0.028); the DQB1 susceptible alleles were DQB1*0201 ( OR =2.24, P (c)<0.001), DQB1*0303 ( OR =1.30, P (c)=0.030), DQB1*0304 ( OR =10.23, P (c)=0.004) and DQB1*0401( OR =1.94, P (c)<0.001); and the DRB1 susceptible alleles were DRB1*0301 ( OR =2.10, P (c)<0.001), DRB1*0405( OR =1.89, P (c)<0.001) and DRB1*0901( OR =1.36, P (c)=0.008), respectively in Chinese Han nationality LADA patients. The HLA-Ⅱ susceptible genotypes were DQA1*03/05 ( OR =1.81, P (c)=0.007), DQB1*0201/0201( OR =5.74, P (c)<0.001), DQB1*0201/0303 ( OR =2.58, P (c)=0.010), DRB1*0301/0901( OR =3.43, P (c)=0.028) and DRB1*0901/0901 ( OR =1.82, P (c)=0.021), respectively in LADA patients. DQB1*0201 and DRB1*0301 were shared susceptible alleles for Chinese Han and Caucasian LADA patients, while DQA1*03, DQB1*0303, DQB1*0304, DQB1*0401, DRB1*0405 and DRB1*0901 were specific susceptible alleles for Chinese Han LADA patients. Interestingly, the DQB1*0303 allele was susceptible in Chinese while protective in Caucasian ( OR: 1.30 vs 0.29). Conclusion: Susceptible alleles are DQA1*03, DQB1*0201, DQB1*0303, DQB1*0304, DQB1*0401, DRB1*0301, DRB1*0405 and DRB1*0901, and susceptible genotypes are DQA1*03/05, DQB1*0201/0201, DQB1*0201/0303, DRB1*0301/0901 and DRB1*0901/0901 in Chinese LADA patients.

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