Add like
Add dislike
Add to saved papers

Modulation of neuro-inflammatory condition, acetylcholinesterase and antioxidant levels by genistein attenuates diabetes associated cognitive decline in mice.

The association of diabetes and cognitive decline may indicate that high sugar level might be a risk factor for Alzheimer's disease. A collective term 'diabetes associated cognitive decline' (DACD) has been coined for the patients with type 2 diabetes mellitus showing decline in their cognitive function, especially weak episodic memory, cognitive inflexibility and poor psychomotor performance leading towards Alzheimer's disease. However, at present, no specific treatment exists for the prevention and/or treatment of DACD. Genistein, an isoflavone phytoestrogen, reveals neuroprotective effects in many experimental murine models, though its role on DACD with probable mechanistic approach has still been scope for research. The motive behind the present study is to investigate the outcome of genistein treatment against DACD in streptozotocin-induced diabetic mice with Morris water maze paradigm followed by open field trial to rule out the possibility of impairment in locomotor performance. Chronic (30 days) genistein treatment (2.5, 5.0 and 10.0 mg/kg, i.p. once daily) in diabetic mice significantly lowered hyperglycemia, recovered cognitive performance by affecting acetylcholinesterase activity and oxidative stress and ameliorated neuro-inflammatory condition by varying TNF-α, IL-1β and nitrite levels as impaired in diabetic mice. Thirty days treatment with vitamin C or metformin also improved diabetes-induced memory impairment and significantly dragged these biochemical parameters towards respective controls. Locomotor performance was not influenced by diabetic condition or any associated treatment. It is concluded that genistein supplementation might be a prospective therapeutic approach for the treatment and/or avoidance of diabetic linked learning and memory dysfunction.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app