We have located links that may give you full text access.
Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
Pathology, Research and Practice 2017 May
Both phosphorylated 4E binding protein 1 (p-4E-BP1) and eukaryotic translation initiation factor 4E (eIF-4E) play an important role in cancer progression. The aim of this study is to evaluate the expression of p-4E-BP1 and eIF-4E in human colorectal cancer (CRC) and to assess their clinical significance. Expression levels of two markers were analyzed in surgical specimens from 116 CRC cases by immunohistochemical staining. Their clinical significance as well as the two proteins' correlation was also investigated. Western blot was also used to detect the protein expressions in CRC cell lines. High p-4E-BP1 expression was significantly associated with lymphovascular invasion (LVI) (p=0.003), perineural invasion (PNI) (p=0.001), tumor stage (p=0.024), nodal stage (p=0.000), metastatic status (p=0.027), and disease stage (p=0.001). High eIF-4E expression had significant correlations with LVI (p=0.001), PNI (p=0.008), nodal stage (p=0.018), metastatic status (p=0.024) and disease stage (p=0.030). Pearson correlation calculations showed a weakly positive correlation between p-4E-BP1 and eIF-4E immunoreactivity (p=0.037). Patients with low eIF-4E expressions tended to have significantly longer overall survival (p=0.039). Western blot analysis showed higher expression of p-4E-BP1 and eIF-4E proteins in CRC cell lines compared with normal colon tissue. In conclusions, high expressions of eIF-4E are associated with advanced stage and poor prognosis. These data suggest that eIF-4E may provide a helpful therapeutic target in treatment of CRC.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app