Late-stage parenchymatous neurosyphilis presenting as general paresis of insane, Poland – case report

We describe a very rare case of late-stage parenchymatous neurosyphilis, presenting as general paresis of insane, diagnosed in a 44-year-old male truck driver. Probable place of exposition was Belarus. An appropriate clinical examination, laboratory diagnostics, and subsequent effective treatment and follow-up in accordance with evidence-based management guidelines are essential to avoid irreversible sequelae in these late-stage neurosyphilis patients. Increased awareness that rare cases of parenchymatous neurosyphilis still exist in the 21st century is crucial and this entity should still be considered in differential diagnosis in patients with neuropsychiatric symptoms such as memory or cognitive impairment.