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A new and potentially prebiotic α-cytidine derivative.

Maria Tsanakopoulou, Jianfeng Xu, Andrew D Bond, John D Sutherland
Chemical Communications : Chem Comm 2017 March 17
A new α-cytidine derivative was synthesised from the prebiotic reaction of ribose aminooxazoline and dicyanoacetylene. The tetracyclic structure of the product was confirmed by X-ray diffraction and then an alternative 6-step synthetic pathway to the product was found which was suitable for large-scale synthesis.

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