SiMEA: a framework for simulating neurons on multi-electrode array.

A Multi-Electrode Array (MEA) is a practical device for recording the extracellular activity of in-vitro biological culture. Such culture - for instance neurons - is prone to mistakes leading to irrelevant recordings or no recording at all. Additionally, with the expenses generated by in-vitro culture, minimizing risks is a must. This paper proposes a framework designed and implemented for simulating the spatial positioning of neuronal cultures on a MEA. The framework serves as a sandbox for researchers to simulate the model of their MEA experiments before its eventual in-vitro implementation. The framework enables simulating the density of the plated culture, the death of cells over time, choosing diverse reconstructed morphologies of cells, and simulating their spiking activity in interaction with Brian2 simulator.