Brain activation profiles in mTBI: evidence from ERP activity of working memory response.

In this study we analyzed event related potentials (ERPs) obtained in an N-back working memory test that varied in difficulty from 0- to 2-back. We collected 21 channels of activity from 11 mild traumatic brain injury (mTBI) patients and 7 normal controls, on three different visits, and used the amplitude and latency of the P300 component to characterize the subjects. A preprocessing procedure based on independent component analysis was used first to identify and eliminate electrophysiological noise on a single trial basis. Then to obtain more reliable statistics, the recording electrodes were lumped into five main groups corresponding roughly to frontal, central, parietal, and left and right temporal brain regions. For each subject, the P300 amplitude and latency were measured after averaging the activity of all channels in each group. Group analyses showed that latencies in the central region were significantly shorter in controls, at every visit for the 2-back test. The lack of significant differences across the three visits for the mTBI group indicates that mTBI subjects are not improving at the rate that might have been expected, confirming previous reports that mTBI deficits may persist for years.